Rnf152 rheb
WebIn this review, we focus on E3 ligases, RNF183, RNF186, RNF182, and RNF152, which are closely related genes encoding a RING-finger domain (C3HC4) at its N-terminus and one … WebSep 25, 2024 · The RNF152 transcription level was significantly higher in FoxA2-overexpressing explants than in GFP-electroporated explants, suggesting that RNF152 is …
Rnf152 rheb
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WebDec 4, 2024 · We found that RNF152 preferentially bound to GDP-loaded Rheb (Fig. 2f), indicating that the interaction between Rheb and RNF152 is affected by the nucleotide … Web29 interacting genes: a2m apoe appbp2 arih2 atm atr bnip3 bnip3l braf creb3 ecsit fkbp8 htt mtor ncam1 pde6d pld1 psen1 psen2 rabac1 raf1 rnf152 rps6kb1 rptor trim55 trim63 tsc1 …
As a key negative regulator of mTORC1 signaling pathway, the TSC complex was reported to mainly function as a GAP to inactivate Rheb GTPase17. Surprisingly, we found that the expression of TSC1, TSC2, or TBC1D7 promoted Rheb ubiquitination in HEK293T cells (Fig. 1a, Supplementary information, Fig. S1a, b). … See more Since ubiquitination is usually catalyzed by E3 ubiquitin ligase, we screened a panel of E3 ligases to identify the specific E3 ligase for Rheb ubiquitination. We … See more We next investigated whether RNF152 is involved in TSC2-mediated Rheb ubiquitination. Our data showed that ectopical expression of RNF152 enhanced TSC2 … See more Ubiquitination is a reversible process that is counteracted by deubiquitination20,34. To identify the deubiquitinase of Rheb, we screened a wide variety of DUBs … See more Since our data showed that Rheb ubiquitination was inhibited by EGF treatment (Fig. 1i), we examined whether the interaction between USP4 and Rheb was affected … See more WebDec 1, 2024 · A recent study showed that Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex, which is of regulatory …
WebRHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.. RHEB is a recently discovered member of the Ras superfamily.Being a relative of Ras, the overexpression of RHEB can be seen in … WebJan 18, 2016 · Rag small GTPases were identified as the sixth subfamily of Ras-related GTPases. Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) …
WebRNF152 is an E3 ubiquitin ligase with RING domain and single-pass transmembrane (TM) domain, which is mainly localized in lysosomes . RNF152 exhibits pro-apoptotic activity …
WebFunctionally, ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth. Thus, we propose a mechanistic model whereby … can you get wine shipped to alabamaWebBioGRID Interaction 2624053 Between RNF152 And RHEB. Toggle navigation. Bio GRID 4.4 can you get winter coats tailoredWebE3 Ubiquitin-Protein Ligase RNF152 (RNF152) Antibody. abx226243 is a primary antibody from Abbexa. 0 Citations Host: Rabbit Clonality: Polyclonal Validations: None Available … can you get winter fuel allowance at 60WebThe gene encoding RNF152 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases … can you get wireless cable tvWebOct 21, 2015 · A tag already exists with the provided branch name. Many Git commands accept both tag and branch names, so creating this branch may cause unexpected … can you get wizz on pcWebFunctionally, ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth. Thus, we propose a mechanistic model whereby … can you get wireless headphones for tvWebPTHR24070 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY 1 hit; PRINTS. PR00449 RASTRNSFRMNG; PROSITE. View protein in PROSITE; PS51421 … can you get wisdom teeth at 30