Web1 sep. 2016 · HepG2, a human hepatocellular carcinoma line, was obtained from ECACC (Salisbury,UK) and was maintained in DMEM supplemented with 10% FBS and p/s. Lipofectamine (Invitrogen) was used for the transfection of the Srebp-2 plasmid (pcDNA3.1-2xFLAG-SREBP-2, gift from Timothy Osborne, Addgene plasmid # 26807) [ 50] or the … Web8 apr. 2024 · Nonalcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes mellitus (T2DM) have highly related mechanisms. Ramulus Mori (Sangzhi) alkaloids (SZ-A) from Morus alba L. were approved in 2024 for the treatment of T2DM. In this study, we examined the therapeutic effects and mechanism of SZ-A on obesity and NAFLD in mice. Mice …
Arg-tRNA synthetase links inflammatory metabolism to RNA …
Web12 apr. 2024 · Journal Pre-proof Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism Gabriel Chalhoub, Alina Jamnik, Laura Pajed, Stephanie Kolleritsch, Victoria Hois, Antonia Bagaric, Dominik Prem, Anna Tilp, Dagmar Kolb, Heimo Wolinski, Ulrike … Web30 mrt. 2024 · In this study, we demonstrated that PG induced antioxidant enzymes through activating the Nrf2/ARE pathway in HepG2 cells and the liver of mice for the first time. Thus, PG might be an attractive compound for the protection of liver from oxidative stress as a potential antioxidant through the induction of antioxidant enzymes. eating places carlsbad nm
Carboxylesterase 2a deletion provokes hepatic steatosis and …
Web9 apr. 2024 · Interestingly, IARS1 V79L mice showed a significant increase in serum OCT levels, indicating that IARS hypofunction induces mitochondrial hepatopathy . Moreover, IARS1-KD HepG2 cells showed a decrease in mitochondrial membrane potential and increased ROS production, indicating mitochondrial dysfunction. Web12 apr. 2024 · Journal Pre-proof Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and … WebHepG2 was derived from a liver hepatocellular carcinoma of a 15 year old Caucasian male. Age 15 years Ethnicity White Gender Male Karyotype modal number = 55 (range = 50 to 60); has a rearranged chromosome 1 Tumorigenic No; No, in immunosuppressed mice Yes, in semisolid medium Genes expressed companies for business analyst