Cisplatin induced apoptosis

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August undefined, 2024

WebSep 8, 2016 · To assess cisplatin-induced hair cell apoptosis, we used immunofluorescence staining of cleaved caspase 3, a common executor in the apoptotic pathway. 23 Cochlear explants were transfected with ... WebApr 1, 2016 · By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells.

Role of ferroptosis in cisplatin-induced acute ... - ScienceDirect

WebTo study the mechanism of apoptosis induced by cisplatin in vitro in HeLa cells cervical cancer cell line. The inhibitory effect of cisplatin on HeLa cell growth was analyzed by … WebMoreover, DSF sensitized ovarian cancer cells to cisplatin treatment and enhanced cisplatin-induced apoptosis, both in SDC and MDC. In the present studies, we have used a quantitative method to determine synergism or antagonism of DSF in chemotherapy drug treatment. Three pairs of two-drug combinations and a three-drug combination were … small log cabins for sale in wisconsin

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebJan 17, 2024 · Cisplatin-induced nephrotoxicity can occur from several pathways, including extrinsic apoptosis and intrinsic apoptosis that can trigger AIF expression, cell regulators, MAPK, inflammation, and ROS. Meanwhile, apoptosis in the negative control group (P0) can be caused by physiological processes that can be experienced by all cells. WebOn the contrary, coadministration of 4-PBA reduces the expression of GRP78 and CHOP and enhances apoptosis in cisplatin-treated osteosarcoma cell lines, indicating that cisplatin-induced ER stress protects cell from apoptosis in these cell lines . WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … small log cabins for sale in nc mountains

Is Cisplatin-Induced Cell Death Always Produced by …

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WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. WebRenal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has... higher shoes还直播吗WebNov 3, 2024 · Apoptosis is known as one of the major mechanisms of cisplatin-induced cell death in renal tubular which had been further confirmed in some studies [ 5, 6 ]. Some research data have also demonstrated that autophagy induction is an immediate response of renal tubular epithelial cell exposure to cisplatin [ 7, 8 ]. highcharts dark mode

"WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. We have assessed in detail the effect of cisplatin-activated programmed cell death … " - Cisplatin induced apoptosis

Cisplatin induced apoptosis

WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … WebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by …

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WebJul 1, 1999 · The results thus far suggest that CP70 and C30 cells initiate apoptosis via a caspase-3-dependent pathway. However, even in the absence of caspase-3 activation, A2780 cells do exhibit some morphological characteristics of cisplatin-induced apoptosis, including a subset of the biochemical features of PCD. WebThe chemotherapeutic cisplatin causes renal dysfunction and renal proximal tubular cell (RPTC) apoptosis. The goal of these studies was to examine the role of p53, caspase 3, 8, and 9, and mitochondria in the signaling of cisplatin-induced apoptosis. Cisplatin (50 microM) produced time-dependent apo …

WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su …

Web2-ME promoted the growth inhibitory and apoptosis-inducing effects of platinum-based agents in SKOV3 ovarian cancer cells and promoted the mRNA and protein expression of Bax, thereby, increasing the Bax/Bcl-2 expression ratio and activating the mitochondrial apoptosis pathway. 8 PDF WebOct 5, 2014 · Cisplatin-Induced Cell Apoptosis Apoptosis is a controlled type of cell death which is energy-dependent leading to cell shrinkage, chromatin condensation, …

WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin is …

WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … higher duties forgovWebFeb 10, 2024 · Apoptosis and cell cycle analysis also showed that BCAAs or Leu treatment significantly increased cisplatin-induced apoptosis (Figure S3A) and reduced the proportion of cells in G2/M phase after ... small log cabins for sale near meWebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant … small log cabins maineWebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … small log cabins for sale in ohioWebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. higher dose pemf mat settingsWebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within 24–48 hr requires cisplatin concentrations that are … small log cabins in washington state for saleWebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. small log cabins amish made